Cohen A M, Teitelbaum A, Miller E, Ben-Tor V, Hirt R, Fields M
Isr J Med Sci. 1982 Aug;18(8):840-4.
Rats fed a copper-poor diet were found to have a reduced plasma insulin response to an oral glucose load in comparison with rats fed a copper-supplemented diet. In addition, the increment in plasma glucose above the fasting level at 60 min and at 120 min was significantly higher in rats maintained on the copper-poor diets. In vitro glucose incorporation into diaphragm glycogen and into epididymal fat-pad lipids was stimulated greater than twofold by the addition of 100 micrograms/ml CuCl2 to the incubation medium. In tissues of streptozotocin-diabetic rats, the stimulatory effect of copper on glucose incorporation in vitro was also noted, but was significantly smaller. These results indicate that glucose utilization by peripheral tissues and insulin release may be added to the many vital functions for which copper is essential.
与喂食补充铜饮食的大鼠相比，发现喂食低铜饮食的大鼠对口服葡萄糖负荷的血浆胰岛素反应降低。此外，在60分钟和120分钟时，低铜饮食喂养的大鼠血浆葡萄糖高于空腹水平的增量显著更高。向孵育培养基中添加100微克/毫升氯化铜可使体外葡萄糖掺入膈肌糖原和附睾脂肪垫脂质的量增加两倍以上。在链脲佐菌素诱导的糖尿病大鼠组织中，也观察到铜对体外葡萄糖掺入的刺激作用，但显著较小。这些结果表明，外周组织的葡萄糖利用和胰岛素释放可能被添加到铜所必需的许多重要功能中。
