Cohen D, Eisdorfer C, Leverenz J
J Am Geriatr Soc. 1982 Oct;30(10):656-9. doi: 10.1111/j.1532-5415.1982.tb05065.x.
Findings from several studies suggest a relationship between Alzheimer's disease and Down's syndrome. It has long been known that advanced maternal age is a risk factor for Down's syndrome, and that mothers who give birth to a child with this syndrome have characteristics consistent with accelerated aging. Little is known about risk factors for Alzheimer's disease, other than age. In this study, documentation is supplied for a hypothesis concerning a relationship between Alzheimer's disease and advanced maternal age.
多项研究结果表明阿尔茨海默病与唐氏综合征之间存在关联。长期以来,人们都知道高龄产妇是唐氏综合征的一个风险因素,并且生下患有该综合征孩子的母亲具有与加速衰老相一致的特征。除了年龄之外,对于阿尔茨海默病的风险因素知之甚少。在本研究中,提供了关于阿尔茨海默病与高龄产妇之间关系的一种假说的文献依据。