Corkin S, Growdon J H, Rasmussen S L
Ann Neurol. 1983 Jun;13(6):674-6. doi: 10.1002/ana.410130618.
Because of the associations between Alzheimer's disease and Down's syndrome, advanced maternal and paternal age, which are risk factors for Down's syndrome, have been proposed as risk factors for Alzheimer's disease. Parental age data were obtained from a group of patients with Alzheimer's disease and compared with comparable data for a group of nondemented subjects matched for age and socioeconomic level. As a way of detecting a familial causative factor in Alzheimer's disease, life-span data were also collected for parents of patients and control subjects. The results indicated that patients with Alzheimer's disease and nondemented control subjects did not differ in the mean ages of their parents at the time of the patients' or subjects' births, nor did parental age correlate significantly with age at onset of disease. Moreover, the parents of patients with Alzheimer's disease did not differ in mean age at death from the parents of nondemented control subjects.
由于阿尔茨海默病与唐氏综合征之间存在关联，而高龄产妇和高龄父亲是唐氏综合征的风险因素，因此有人提出这也是阿尔茨海默病的风险因素。从一组阿尔茨海默病患者中获取父母年龄数据，并与一组年龄和社会经济水平相匹配的非痴呆受试者的相应数据进行比较。作为检测阿尔茨海默病家族致病因素的一种方法，还收集了患者和对照受试者父母的寿命数据。结果表明，阿尔茨海默病患者与非痴呆对照受试者出生时其父母的平均年龄并无差异，父母年龄与疾病发病年龄也无显著相关性。此外，阿尔茨海默病患者的父母在平均死亡年龄上与非痴呆对照受试者的父母并无差异。
