Delbeke J, Kopec J, McComas A J
J Neurol Neurosurg Psychiatry. 1978 Jan;41(1):65-71. doi: 10.1136/jnnp.41.1.65.
Absolutely and relatively refractory periods have been investigated in terminal median nerve axons and in thenar muscle fibres in a variety of pathophysiological conditions. Marked increased in refractoriness were produced by cooling to 20 degrees C. Nerve fibre refractoriness was more pronounced in older subjects and diminished in myotonic dystrophy. In contrast, no significant changes in muscle fibre excitability could be demonstrated in either condition or in patients with renal failure or motor neuropathies.
在多种病理生理条件下，已对正中神经终末轴突和鱼际肌纤维的绝对不应期和相对不应期进行了研究。冷却至20摄氏度会使不应期明显延长。神经纤维不应期在老年受试者中更明显，而在强直性肌营养不良中则减弱。相比之下，在上述任何一种情况下，以及在肾衰竭或运动神经病患者中，均未发现肌纤维兴奋性有显著变化。
