Yefenof E, Zilcha D
Int J Cancer. 1982 Sep 15;30(3):355-9. doi: 10.1002/ijc.2910300316.
Adult C57BL/6 mice inoculated intrathymically (i.t.) with the highly leukemogenic variant of the radiation leukemia virus (A-RadLV) develop suppressor cells capable of specifically abrogating a potential anti-tumor cytotoxic response in vitro. Suppressor cells were generated directly by the virus, independently of an initiation of a leukemogenic process. Inoculation of C57BL/6 animals with the low leukemogenic D-RadLV variant did not result in suppressor cell generation. It is proposed that induction of tumor-specific immune suppression by A-RadLV is essential for tumor progression, and the leukemogenic activity of D-RadLV is attributed to its inability to recruit suppressor cells.
经胸腺内（i.t.）接种辐射白血病病毒（A-RadLV）的高致白血病变体的成年C57BL/6小鼠会产生抑制细胞，这些抑制细胞能够在体外特异性消除潜在的抗肿瘤细胞毒性反应。抑制细胞由病毒直接产生，与致白血病过程的启动无关。用低致白血病的D-RadLV变体接种C57BL/6动物不会导致抑制细胞的产生。有人提出，A-RadLV诱导肿瘤特异性免疫抑制对肿瘤进展至关重要，而D-RadLV的致白血病活性归因于其无法募集抑制细胞。
