Haran-Ghera N, Rubio N
J Immunol. 1977 Feb;118(2):607-11.
Comparative analysis of immune responses induced by two variants of the radiation leukemia virus having high (A-RadLV) or low (D-RadLV) leukemogenic potential was performed. Effective immunization could be induced only with RadLV variants having low leukemogenic potential when injected into adult mice of specific strains, (D-RadLV in C57BL/6 mice and A-RadLV in (BALB/c X C57BL/6)F1 mice). Immunologic cross-reactivity among the RadLV variants and the leukemic cells induced by them was demonstrated in several systems. Transplantation resistance could be induced in certain strains against challenge of leukemic cells induced by both RadLV variants. Isoantisera, raised in the suitable strains, could neutralize effectively the leukemogenic activity of both A-RadLV and D-RadLV. Leukemic cells induced by each of the variants shared cell-surface antigens. Circulating anti-tumor antibodies, induced by both variants in the appropriate strains, lysed efficiently the target leukemic cells.
对具有高致白血病潜力（A-RadLV）或低致白血病潜力（D-RadLV）的两种辐射白血病病毒变体诱导的免疫反应进行了比较分析。当将具有低致白血病潜力的RadLV变体注射到特定品系的成年小鼠中时（C57BL/6小鼠中的D-RadLV和（BALB/c×C57BL/6）F1小鼠中的A-RadLV），才能诱导有效的免疫。在几个系统中证明了RadLV变体与其诱导的白血病细胞之间的免疫交叉反应性。在某些品系中可以诱导移植抗性，以抵抗由两种RadLV变体诱导的白血病细胞的攻击。在合适的品系中产生的同种抗血清可以有效中和A-RadLV和D-RadLV的致白血病活性。由每种变体诱导的白血病细胞共享细胞表面抗原。在合适的品系中由两种变体诱导的循环抗肿瘤抗体有效地裂解了靶白血病细胞。
