Yefenof E, Ben David Y, Kotler M
Int J Cancer. 1984 Dec 15;34(6):875-82. doi: 10.1002/ijc.2910340621.
C57BL/6 (B6) mice inoculated with the highly leukemogenic variant of the radiation leukemia virus (A-RadLV) develop suppressor cells capable of abrogating potential anti-tumor immunity in vitro and in vivo. Inoculation of B6 animals with the low-leukemogenic D-RadLV variant does not result in suppressor cell generation but induces antitumor reactive lymphocytes. A-RadLV and D-RadLV are not leukemogenic in BALB/c or (B6 X BALB/c)F1(F1) mice, and reactive but not suppressor lymphocytes could be demonstrated in F1 animals inoculated with either virus. Infectivity assays and fingerprint analysis revealed that A-RadLV and D-RadLV contain viruses with N and B tropism. In addition, thymoma cells induced by A-RadLV produced another virus with a fingerprint pattern containing X-MuLV elements. The possible implications of the different virus types on the immunogenic and leukemogenic properties of the RadLV variants are discussed.
接种辐射白血病病毒（A-RadLV）高致白血病变体的C57BL/6（B6）小鼠会产生抑制细胞，这些抑制细胞在体外和体内均能消除潜在的抗肿瘤免疫。用低致白血病的D-RadLV变体接种B6动物不会导致抑制细胞的产生，但会诱导抗肿瘤反应性淋巴细胞。A-RadLV和D-RadLV在BALB/c或（B6×BALB/c）F1（F1）小鼠中不具有致白血病性，在用任何一种病毒接种的F1动物中都可证明存在反应性淋巴细胞而非抑制性淋巴细胞。感染性测定和指纹分析表明，A-RadLV和D-RadLV含有具有N和B嗜性的病毒。此外，由A-RadLV诱导的胸腺瘤细胞产生了另一种具有包含X-MuLV元件指纹图谱的病毒。本文讨论了不同病毒类型对RadLV变体免疫原性和致白血病性的可能影响。
