注射组织型纤溶酶原激活剂诱导的动物纤溶系统变化。
Changes of the fibrinolytic system of animals induced by injection of tissue plasminogen activator.
作者信息
Andreenko G V, Lyutova L V, Shimonaeva E E
出版信息
Thromb Res. 1982 Aug 1;27(3):279-88. doi: 10.1016/0049-3848(82)90075-5.
The changes in the fibrinolytic system of rats induced by repeated injections of tissue plasminogen activator (TPA) have been studied. The euglobulin fraction fibrinolytic activity increases 10 min after the first injection of TPA. Repeated injections of TPA for one or more days do not stimulate the fibrinolytic activity or TPA accumulation in the blood. Apparently in the absence of fibrin clots in the blood flow of healthy animals TPA is incapable of activating plasminogen conversion into plasmin. TPA, in its turn, is rapidly bound to the antiactivator and is excreted from the organism.
已经研究了反复注射组织型纤溶酶原激活剂（TPA）对大鼠纤溶系统的影响。首次注射TPA后10分钟，优球蛋白部分的纤溶活性增加。连续一天或多天反复注射TPA不会刺激纤溶活性或血液中TPA的积累。显然，在健康动物的血流中不存在纤维蛋白凝块的情况下，TPA无法激活纤溶酶原转化为纤溶酶。反过来，TPA会迅速与抗激活剂结合并从体内排出。
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