Bolte H D, Fischer S, Ludwig B
Z Kardiol. 1982 Aug;71(8):517-21.
Immunological data in dilated cardiomyopathies can differentiate the nosology of these diseases. In nearly one half of these dilated cardiomyopathies, binding of immunoglobuline in myocardial structures (biopsies) can be demonstrated. By immunohistological techniques collagen I in myocardial biopsies has been predominantly shown. In lymphocytes of the diseases patients the T-cell-suppressor activity is low. This phenomenon seems to play an important role in the pathogenesis of dilated cardiomyopathies and can explain numerous humoral immunological findings. As conclusion the hypothesis can be drawn: several cases of dilated cardiomyopathies and myocarditis can be regarded as different stages of a single underlying disease, in which a low T-cell-suppressor activity seems to act as a predisposing factor.
扩张型心肌病的免疫学数据能够区分这些疾病的分类学。在几乎一半的此类扩张型心肌病中，可证明免疫球蛋白在心肌结构（活检组织）中的结合。通过免疫组织学技术，主要显示出心肌活检组织中的I型胶原蛋白。在这些疾病患者的淋巴细胞中，T细胞抑制活性较低。这种现象似乎在扩张型心肌病的发病机制中起重要作用，并且可以解释众多体液免疫的发现。作为结论，可以得出这样的假设：几例扩张型心肌病和心肌炎可被视为单一潜在疾病的不同阶段，其中低T细胞抑制活性似乎是一个易感因素。
