Peters H J, Weissbach L, Nuri M
Dtsch Med Wochenschr. 1982 Oct 29;107(43):1630-4. doi: 10.1055/s-2008-1070178.
In a multicenter randomised clinical comparative study 96 urological patients with established urinary tract infection were treated in 50% with 2 g mezlocillin three times and in 50% with 1.5 g cefuroxime three times. Both antibiotics were shown to be antibacterially active substances with a high bacterial elimination rate. Three days after cessation of treatment the urine was sterile in 79 cases. Follow-up investigations 1-2 weeks later showed that the number of recurrences and reinfections was higher in the cefuroxime group than in the mezlocillin group. This difference is statistically significant so that mezlocillin can be considered the more effective antibiotic. Clinical and urine cytological results correlated with bacteriological results. Side effects were observed rarely, and toxic effects not at all.
在一项多中心随机临床对照研究中，96例确诊为尿路感染的泌尿科患者，50%接受每日3次2克美洛西林治疗，50%接受每日3次1.5克头孢呋辛治疗。两种抗生素均显示为具有高细菌清除率的抗菌活性物质。治疗停止3天后，79例患者尿液无菌。1 - 2周后的随访调查显示，头孢呋辛组的复发和再感染次数高于美洛西林组。这种差异具有统计学意义，因此美洛西林可被认为是更有效的抗生素。临床和尿液细胞学结果与细菌学结果相关。副作用很少见，未观察到毒性作用。
