Verpoorte R, Baerheim Svendsen A
J Pharm Sci. 1978 Feb;67(2):171-4. doi: 10.1002/jps.2600670213.
Three alkaloids of the stem bark of Strychnos dolichothyrsa Gilg ex Onochie et Hepper (Loganiaceae) were isolated and identified as caracurine V and its mono- and di-N-oxide by comparison with synthesized compounds. 13C-NMR was used to confirm the structure of the N-oxides. The muscle relaxant activity and the toxicity of the N-oxides were less than those of caracurine V.
从多籽马钱(马钱科,学名:Strychnos dolichothyrsa Gilg ex Onochie et Hepper)的茎皮中分离出三种生物碱,通过与合成化合物比较,鉴定为卡拉库林V及其单-N-氧化物和二-N-氧化物。利用13C-核磁共振来确认N-氧化物的结构。N-氧化物的肌肉松弛活性和毒性低于卡拉库林V。