Rolfsen W N, Olaniyi A A, Hylands P J
J Nat Prod. 1980 Jan-Feb;43(1):97-102. doi: 10.1021/np50007a007.
From the stem bark of Strychnos decussata (Pappe) Gilg (Loganiaceae), five tertiary indole alkaloids have been isolated and identified. Previously known alkaloids, but new to this plant, were: akagerine (1) and 17-O-methylakagerine (2), while alkaloids newly found in nature were 10-hydroxy-21-O-methylkribine (3a), 10-hydroxyepi-21-O-methylkribine (3b) and 10-hydroxy-17-O-methylakagerine (4). Structures have been ascribed to the new compounds on the basis of their spectral, particularly nmr, data. The pharmacological activity of the alkaloids is also discussed.
从交互木（马钱科）的茎皮中，已分离并鉴定出五种叔吲哚生物碱。之前已知但该植物中首次发现的生物碱有：阿卡吉林（1）和17 - O - 甲基阿卡吉林（2），而自然界中新发现的生物碱有10 - 羟基 - 21 - O - 甲基克里宾（3a）、10 - 羟基表 - 21 - O - 甲基克里宾（3b）和10 - 羟基 - 17 - O - 甲基阿卡吉林（4）。已根据新化合物的光谱数据，尤其是核磁共振数据确定了其结构。还讨论了这些生物碱的药理活性。
