下丘脑外加压素在帕金森病和亨廷顿病中无变化。

Extrahypothalamic vasopressin is unchanged in Parkinson's disease and Huntington's disease.

作者信息

Rossor M N, Hunt S P, Iversen L L, Bannister R, Hawthorn J, Ang V T, Jenkins J S

出版信息

Brain Res. 1982 Dec 16;253(1-2):341-3. doi: 10.1016/0006-8993(82)90706-5.

Abstract

Vasopressin immunoreactivity was measured post-mortem in the locus coeruleus and substantia nigra of 16 cases of Parkinson's disease and multisystem atrophy, 10 cases of Huntington's chorea and 28 normal controls. Amounts of vasopressin did not differ significantly (P greater than 0.05) between the 3 groups. Immunohistochemistry demonstrated vasopressin within nerve terminals. These data are consistent with an extrinsic vasopressin system in the human locus coeruleus and substantia nigra.

摘要

对16例帕金森病和多系统萎缩患者、10例亨廷顿舞蹈症患者以及28名正常对照者进行尸检，检测蓝斑和黑质中加压素免疫反应性。3组之间加压素含量无显著差异（P>0.05）。免疫组织化学显示神经末梢内存在加压素。这些数据与人类蓝斑和黑质中的外源性加压素系统一致。