人脑中的下丘脑外血管加压素。

Extrahypothalamic vasopressin in human brain.

作者信息

Rossor M N, Iversen L L, Hawthorn J, Ang V T, Jenkins J S

出版信息

Brain Res. 1981 Jun 15;214(2):349-55. doi: 10.1016/0006-8993(81)91199-9.

Abstract

The distribution of arginine vasopressin immunoreactivity in post-mortem human brain was examined using a radioimmunoassay. The highest concentration was found in the hypothalamus but substantial amounts of vasopressin-like immunoreactivity were also found in the locus coeruleus, periaqueductal grey, substantia nigra compacta and reticulata and in lower concentrations in the globus pallidus. The extrahypothalamic vasopressin was immunologically and chromatographically similar to hypothalamic vasopressin. The possibility arises that the high levels of vasopressin in the locus coeruleus may relate to an effect on noradrenergic transmission.

摘要

使用放射免疫分析法检测了精氨酸加压素免疫反应性在人死后大脑中的分布。在下丘脑中发现了最高浓度，但在蓝斑、导水管周围灰质、黑质致密部和网状部也发现了大量的加压素样免疫反应性物质，在苍白球中的浓度较低。下丘脑外的加压素在免疫学和色谱学上与下丘脑加压素相似。由此产生一种可能性，即蓝斑中高水平的加压素可能与对去甲肾上腺素能传递的影响有关。