Wittmann D H, Schassan H H
Rev Infect Dis. 1982 Nov-Dec;4 Suppl:S610-6. doi: 10.1093/clinids/4.supplement_3.s610.
Concentration-vs.-time curves in serum, peritoneal fluid, bone, and tissue fluid were determined after 2-g intravenous doses of moxalactam. Serum concentrations were measured in five volunteers (group 1; mean age, 22.8 years). Serum and peritoneal fluid concentrations were measured in eight patients (group 2; mean age, 66.5 years). Serum, bone, and tissue fluid concentrations were measured in eight patients (group 3; mean age, 71.5 years). The serum concentrations fitted an open two-compartment model. In groups 1, 2, and 3, the respective serum beta-phase half lives were 134, 169, and 184 min. In group 2, the peak concentration in peritoneal fluid was 43.8 mg/liter after 2.02 hr, with one-quarter of this concentration being maintained for 13 hr. In group 3, the bone concentrations were 19.4 mg/liter after 60 min and 19.1 mg/liter after 120 min; the peak concentration in tissue fluid was 36.1 mg/liter after 2.4 hr, with one-quarter of this concentration being maintained for 15 hr. These concentrations in tissues will inhibit most aerobic and anaerobic bacteria that cause infections.
静脉注射2克拉氧头孢后，测定血清、腹腔液、骨和组织液中的浓度-时间曲线。在5名志愿者（第1组；平均年龄22.8岁）中测量血清浓度。在8名患者（第2组；平均年龄66.5岁）中测量血清和腹腔液浓度。在8名患者（第3组；平均年龄71.5岁）中测量血清、骨和组织液浓度。血清浓度符合开放二室模型。在第1、2和3组中，各自血清β相半衰期分别为134、169和184分钟。在第2组中，腹腔液中的峰值浓度在2.02小时后为43.8毫克/升，该浓度的四分之一维持13小时。在第3组中，骨浓度在60分钟后为19.4毫克/升，120分钟后为19.1毫克/升；组织液中的峰值浓度在2.4小时后为36.1毫克/升，该浓度的四分之一维持15小时。组织中的这些浓度将抑制大多数引起感染的需氧菌和厌氧菌。
