Wittmann D H, Schassan H H, Kohler F, Seidel H
Unfallchirurgie. 1981;7(3):142-6. doi: 10.1007/BF02589729.
After injection of 2 g of moxalactam over 5 minutes in 8 patients with mean age of 71,5 years, serum halflife was found to be T 50% beta = 184 min and the volume of distribution at steady state VDSS = 17,45l, whereas these figures in volunteers with mean age of 22.8 years were T 50% beta = 134 min and VDSS 16,80l respectively. The concentrations in organic bone were 30 to 60 min after injection of 2 g of Moxalactam 19,40 mg/l with a deviation factor of 1,43 and 61 to 120 min after injection 19,08 mg/l with a deviation factor of 1,16. The problems of penetration of antibiotics into bone are discussed. Moxalactam does not penetrate into anorganic bone (hydroxylapatite).
在8名平均年龄为71.5岁的患者中，于5分钟内注射2克羟羧氧酰胺菌素后，发现血清半衰期为T 50%β = 184分钟，稳态分布容积VDSS = 17.45升，而在平均年龄为22.8岁的志愿者中，这些数值分别为T 50%β = 134分钟和VDSS 16.80升。注射2克羟羧氧酰胺菌素后30至60分钟时，有机骨中的浓度为19.40毫克/升，偏差因子为1.43；注射后61至120分钟时，浓度为19.08毫克/升，偏差因子为1.16。文中讨论了抗生素渗入骨骼的问题。羟羧氧酰胺菌素无法渗入无机骨（羟基磷灰石）。
