Wise R, Baker S, Livingston R
Antimicrob Agents Chemother. 1980 Sep;18(3):369-71. doi: 10.1128/AAC.18.3.369.
The pharmacokinetics of cefotaxime and moxalactam were compared in six healthy male volunteers aftr the administration of 1-g doses intravenously. Penetration of the compounds into tissue fluid was studied in cantharides-induced blisters. Both serum and tissue fluid levels of moxalactam were higher than those of cefotaxime. The elimination half-life of cefotaxime was 1.2 h, and that of moxalactam was 2.85 h. On the average, 50.5% of cefotaxime and 87.5% of moxalactam were recovered in the urine in 24 h.
在6名健康男性志愿者静脉注射1克剂量后，对头孢噻肟和拉氧头孢的药代动力学进行了比较。在斑蝥素诱导的水疱中研究了这些化合物向组织液中的渗透情况。拉氧头孢的血清和组织液水平均高于头孢噻肟。头孢噻肟的消除半衰期为1.2小时，拉氧头孢的消除半衰期为2.85小时。24小时内，尿液中头孢噻肟的平均回收率为50.5%，拉氧头孢的平均回收率为87.5%。
