Lauria F, Foà R, Gobbi M, Matutes E, Mantovani W, Incarbone E, Tura S, Catovsky D
Ric Clin Lab. 1982 Oct-Dec;12(4):567-72. doi: 10.1007/BF02909341.
The distribution of T cell subsets and the T colony-forming capacity were assessed in 22 patients with hairy-cell leukemia. An overall increase in the proportion of T gamma cells (31 +/- 15%) and a decrease in Tmu cells (38 +/- 11%) were observed if compared with normal controls (16 +/- 6% for T gamma and 51 +/- 13% for Tmu). In half of the patients, however, these values were normal. T gamma cells were highest in the splenectomized patients and in the 15 non-splenectomized patients T gamma cells were higher in those with active disease. Patients with stable disease or in remission had values close to normal. The T colony-forming capacity of unseparated and enriched T lymphocytes was normal regardless of the T cell subset distribution and clinical stage of the disease. These findings suggest that in HCL, unlike B cell chronic lymphocytic leukemia, the imbalance in Tmu/T gamma ratio does not result in an impairment of the in vitro T colony-forming capacity.
对22例毛细胞白血病患者的T细胞亚群分布和T细胞集落形成能力进行了评估。与正常对照相比（Tγ细胞为16±6%，Tμ细胞为51±13%），观察到Tγ细胞比例总体增加（31±15%），Tμ细胞比例降低（38±11%）。然而，半数患者的这些数值是正常的。脾切除患者的Tγ细胞比例最高，在15例未行脾切除的患者中，处于疾病活动期者的Tγ细胞比例更高。病情稳定或缓解的患者数值接近正常。无论T细胞亚群分布及疾病临床分期如何，未分离及富集的T淋巴细胞的T细胞集落形成能力均正常。这些发现提示，在毛细胞白血病中，与B细胞慢性淋巴细胞白血病不同，Tμ/Tγ比值失衡不会导致体外T细胞集落形成能力受损。
