Bom-van Noorloos A A, Schreuder I, de Groot-Swings G, Ubels-Postma J, von dem Borne A E, Melief C J
Tissue Antigens. 1982 Nov;20(5):352-63. doi: 10.1111/j.1399-0039.1982.tb02251.x.
Neoplastic cells from patients with a variety of B- or non-B/non-T-lymphoid malignancies, including chronic lymphocytic leukemia, various histologic types of non-Hodgkin lymphoma and acute lymphocytic leukemia, showed strong variation with respect to stimulatory capacity in mixed lymphocyte culture (MLC). MLC stimulatory capacity was either normal or strongly decreased in comparison with that of normal lymphocytes despite the expression of HLA-DR antigens and p23,30 ("Ia-like") determinants on the tumor cells of all patients. Strongly decreased stimulatory capacity of HLA-DR-positive tumor cells could not be ascribed to suppressive activity of the tumor cells. Tumor cells from three patients with a T-cell malignancy failed to stimulate in MLC and did not react with anti-p23,30 serum. The decreased stimulatory capacity of many DR-positive neoplastic cells is ascribed either to altered membrane presentation of DR antigens or to the absence of MLC stimulatory determinants specified by genes closely linked to, but different from, those coding for DR.
来自患有各种B淋巴细胞或非B/非T淋巴细胞恶性肿瘤（包括慢性淋巴细胞白血病、各种组织学类型的非霍奇金淋巴瘤和急性淋巴细胞白血病）患者的肿瘤细胞，在混合淋巴细胞培养（MLC）中的刺激能力表现出很大差异。尽管所有患者肿瘤细胞上均表达HLA - DR抗原和p23,30（“Ia样”）决定簇，但与正常淋巴细胞相比，MLC刺激能力要么正常，要么显著降低。HLA - DR阳性肿瘤细胞刺激能力的显著降低不能归因于肿瘤细胞的抑制活性。三名患有T细胞恶性肿瘤患者的肿瘤细胞在MLC中未能产生刺激作用，且不与抗p23,30血清发生反应。许多DR阳性肿瘤细胞刺激能力的降低要么归因于DR抗原膜表达的改变，要么归因于与编码DR的基因紧密连锁但不同的基因所指定的MLC刺激决定簇的缺失。
