异丙肾上腺素诱导BALB/c小鼠下颌下腺DNA合成的年龄依赖性。

Age-dependence of isoproterenol-induced DNA synthesis in submandibular glands of BALB/c mice.

作者信息

Piantanelli L, Brogli R, Bevilacqua P, Fabris N

出版信息

Mech Ageing Dev. 1978 Mar;7(3):163-9. doi: 10.1016/0047-6374(78)90062-3.

PMID:621968

Abstract

The age-dependency of isoproterenol (IPR) induced DNA synthesis was investigated in different organs of Balb/c mice. Although modifications of the physiological rate of DNA synthesis after IPR injection occurred also in liver and spleen, a quasi-linear decrease of the peak of IPR response with advancing age was observed only in submandibular glands. Such a decrease was observed when animals were injected with 10(-4) g IPR per g body weight, lower doses being unable to discriminate between young and old mice. In spite of some differences between mice and rats, the early appearance and linearity of the age-dependency remain common features of IPR response.

摘要

研究了异丙肾上腺素（IPR）诱导的DNA合成在Balb/c小鼠不同器官中的年龄依赖性。尽管注射IPR后肝脏和脾脏的DNA合成生理速率也发生了改变，但仅在下颌下腺中观察到IPR反应峰值随年龄增长呈准线性下降。当给动物注射每克体重10(-4)克IPR时观察到这种下降，较低剂量无法区分年轻和年老小鼠。尽管小鼠和大鼠之间存在一些差异，但IPR反应的年龄依赖性的早期出现和线性仍然是共同特征。