Piantanelli L, Basso A, Muzzioli M, Fabris N
Mech Ageing Dev. 1978 Mar;7(3):171-82. doi: 10.1016/0047-6374(78)90063-5.
In order to assess the relationship between the thymus and aging processes, a linear age-dependent parameter in mice such as the response of the submandibular gland to an injection with isoproterenol has been evaluated in athymic (nude) and thymectomized Balb/c mice. The IPR-induced DNA synthesis is reduced in both experimental groups when compared to untreated normal littermates and is recovered by grafting a neonatal thymus. Moreover, the impairment of IPR response in old animals is recovered to young levels by grafting one neonatal thymus one month before test. Neonatal thymus grafts in old recipients are also able to correct their abnormal serum levels of triiodothyronine and insulin. The influence of neonatal thymus on such non-immunological and age-related parameters suggests that this gland can control aging processes, probably through its implication with the endocrine system.
为了评估胸腺与衰老过程之间的关系，已在无胸腺（裸）小鼠和胸腺切除的Balb/c小鼠中评估了小鼠体内与年龄相关的线性参数，如下颌下腺对异丙肾上腺素注射的反应。与未处理的正常同窝小鼠相比，两个实验组中异丙肾上腺素诱导的DNA合成均减少，并且通过移植新生胸腺可使其恢复。此外，在测试前一个月移植一个新生胸腺，可使老年动物中异丙肾上腺素反应的损伤恢复到年轻水平。老年受体中的新生胸腺移植也能够纠正其三碘甲状腺原氨酸和胰岛素的异常血清水平。新生胸腺对这些非免疫性和与年龄相关的参数的影响表明，该腺体可能通过与内分泌系统的关联来控制衰老过程。
