弓形虫感染小鼠中耐辐射且可黏附塑料的抑制性细胞对未致敏T细胞和B细胞抗体应答的抑制作用。
Suppression of unprimed T and B cells in antibody responses by irradiation-resistant and plastic-adherent suppressor cells in Toxoplasma gondii-infected mice.
作者信息
Suzuki Y, Kobayashi A
出版信息
Infect Immun. 1983 Apr;40(1):1-7. doi: 10.1128/iai.40.1.1-7.1983.
Abstract
In the acute phase of Toxoplasma infection, the function of both helper T and B cells was suppressed in primary antibody responses to dinitrophenol (DNP)-conjugated protein antigens. During the course of infection, the suppressive effect on T cells seems to continue longer than that on B cells, since suppression in responses to sheep erythrocytes, a T-dependent antigen, persisted longer than those to DNP-Ficoll, a T-independent antigen. Plastic-adherent cells from the spleens of Toxoplasma-infected and X-irradiated (400 rads) mice had strong suppressor activity in primary anti-sheep erythrocyte antibody responses of normal mouse spleen cells in vitro. These data suggest that the activation of irradiation-resistant and plastic-adherent suppressor cells causes the suppression of both T and B cells in Toxoplasma-infected mice.
摘要
在弓形虫感染的急性期，辅助性T细胞和B细胞的功能在对二硝基苯酚（DNP）偶联蛋白抗原的初次抗体反应中均受到抑制。在感染过程中，对T细胞的抑制作用似乎比对B细胞持续的时间更长，因为对绵羊红细胞（一种T细胞依赖性抗原）反应的抑制比对DNP-菲可（一种T细胞非依赖性抗原）反应的抑制持续时间更长。来自弓形虫感染并经X射线照射（400拉德）小鼠脾脏的塑料贴壁细胞，在体外对正常小鼠脾细胞的初次抗绵羊红细胞抗体反应中具有很强的抑制活性。这些数据表明，抗辐射且可塑料贴壁的抑制细胞的激活导致了弓形虫感染小鼠中T细胞和B细胞的抑制。
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