Corrêa M, Narayanan P R, Miller H C
J Immunol. 1980 Aug;125(2):749-54.
The immune response of splenic cells to SRBC and LPS or Con A mitogens is suppressed in P. chabaudi-infected mice. When mixed with cells from normal donors, spleen cells from infected mice also suppressed anti-SRBC and mitogenic responses. Suppression was not detected in lymph node cells, bone marrow, or thymocytes from infected mice. Removal of infected red cells had no effect on suppression. The cell population responsible for the suppressive activity was adherent to plastic, resistant to irradiation and anti-Thy-1 plus complement treatment.
在感染恰氏疟原虫的小鼠中，脾细胞对绵羊红细胞（SRBC）以及脂多糖（LPS）或刀豆蛋白A（Con A）促细胞分裂剂的免疫反应受到抑制。当与正常供体的细胞混合时，感染小鼠的脾细胞也会抑制抗SRBC反应和促细胞分裂反应。在感染小鼠的淋巴结细胞、骨髓或胸腺细胞中未检测到抑制作用。去除感染的红细胞对抑制作用没有影响。负责抑制活性的细胞群体可黏附于塑料表面，对辐射以及抗Thy-1加补体处理具有抗性。
