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Novikoff ascites tumor cells contain N-acetyllactosaminide beta 1 leads to 3 and beta 1 leads to 6 N-acetylglucosaminyltransferase activity.

作者信息

van den Eijnden D H, Winterwerp H, Smeeman P, Schiphorst W E

出版信息

J Biol Chem. 1983 Mar 25;258(6):3435-7.

PMID:6219989
Abstract

Novikoff ascites tumor cell homogenate was found to catalyze the transfer of [14C]N-acetylglucosamine from UDP-[14C]GlcNAc to asialo-alpha 1-acid glycoprotein. Mucins appeared to be poor acceptors. Methylation and hydrolysis of the product formed in an incubation with UDP-GlcNAc and asialo-alpha 1-acid [3H]glycoprotein yielded 2,4,6-trimethyl [3H]galactose and 2,3,4-trimethyl [3H]galactose, indicating that N-acetylglucosaminyl residues were introduced to position C-3 and C-6 of the terminal galactoses on the glycoprotein. It is concluded that Novikoff cells contain two N-acetylglucosaminyltransferases which might be involved in the synthesis of linear and branched forms of cell surface polylactosaminoglycans and blood group I/i antigenic structures.

摘要

相似文献

1
Novikoff ascites tumor cells contain N-acetyllactosaminide beta 1 leads to 3 and beta 1 leads to 6 N-acetylglucosaminyltransferase activity.
J Biol Chem. 1983 Mar 25;258(6):3435-7.
2
Biosynthesis of polylactosaminoglycans. Novikoff ascites tumor cells contain two UDP-GlcNAc:beta-galactoside beta 1----6-N-acetylglucosaminyltransferase activities.聚乳糖胺聚糖的生物合成。诺维科夫腹水瘤细胞含有两种UDP - N - 乙酰葡糖胺：β - 半乳糖苷β1----6 - N - 乙酰葡糖胺基转移酶活性。
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J Biol Chem. 1980 Dec 10;255(23):11253-61.
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