Smit J M, Burema J, May J F, Postma D S, Sluiter H J, Steenhuis E J
J Electrocardiol. 1983 Jan;16(1):77-86. doi: 10.1016/s0022-0736(83)80162-9.
A long-term prognostic study of 128 patients with severe chronic obstructive pulmonary disease (initial value for Forced Expiratory Volume in one second, [FEV1] less than or equal to 1,000 ml) with regard to electrocardiographic and lung function parameters as obtained at the entry visit is reported. Many initial ECG-variables and lung function parameters were significantly different between survivors and non-survivors after five years. We used a discriminant analysis to determine which factors actually provided independent information for detection of those subjects with a survival less than five years. In a discriminant analysis of the initial 25 ECG-variables only P-amplitude in lead II and S-amplitude in lead V6 were predictors of five-year survival (diagnostic accuracy 66.1%). In a discriminant analysis in which initial lung function variables were also considered next to the ECG-variables, the best prediction of five-year survival was made by P-amplitude in lead II, increase of FEV1 after thiazinamium i.m., and residual volume as percentage of total lung capacity [RV/TLC, %] (diagnostic accuracy 73.2%).
报告了一项针对128例重度慢性阻塞性肺疾病患者（一秒用力呼气容积[FEV1]初始值小于或等于1000 ml）的长期预后研究，该研究涉及在初诊时获得的心电图和肺功能参数。五年后，许多初始心电图变量和肺功能参数在幸存者和非幸存者之间存在显著差异。我们使用判别分析来确定哪些因素实际上为检测存活时间少于五年的受试者提供了独立信息。在对最初的25个心电图变量进行判别分析时，只有II导联的P波振幅和V6导联的S波振幅是五年生存率的预测指标（诊断准确率66.1%）。在一项判别分析中，除了心电图变量外还考虑了初始肺功能变量，对五年生存率的最佳预测指标是II导联的P波振幅、肌肉注射噻嗪铵后FEV1的增加以及残气量占肺总量的百分比[RV/TLC,%]（诊断准确率73.2%）。
