正常妊娠和子痫前期妊娠中的淋巴细胞亚群。

Lymphocyte subsets in normal and pre-eclamptic pregnancies.

作者信息

Moore M P, Carter N P, Redman C W

出版信息

Br J Obstet Gynaecol. 1983 Apr;90(4):326-31. doi: 10.1111/j.1471-0528.1983.tb08918.x.

DOI:10.1111/j.1471-0528.1983.tb08918.x

PMID:6220733

Abstract

Peripheral blood lymphocyte subsets in normal and preeclamptic pregnancies have been studied by using the monoclonal antibodies OKT3 (T cells), OKT4 (helper/inducer T cells) and OKT8 (suppressor/cytotoxic T cells). In addition the numbers of mononuclear cells bearing Ia and monocyte antigens have been assessed by using the monoclonal antibodies OKIa1 and OKM1. No significant differences were found between 10 normal pregnant and 10 non-pregnant subjects. Ten preeclamptic patients were studied and showed an increase in OKT4-positive helper cells. This was significant in terms of percentage of mononuclear cells but not the absolute numbers or the helper/suppressor (OKT4/OKT8) ratio.

摘要

通过使用单克隆抗体OKT3（T细胞）、OKT4（辅助/诱导性T细胞）和OKT8（抑制/细胞毒性T细胞），对正常妊娠和先兆子痫妊娠的外周血淋巴细胞亚群进行了研究。此外，通过使用单克隆抗体OKIa1和OKM1评估了携带Ia和单核细胞抗原的单核细胞数量。在10名正常孕妇和10名非孕妇之间未发现显著差异。对10名先兆子痫患者进行了研究，结果显示OKT4阳性辅助细胞增加。就单核细胞百分比而言，这具有统计学意义，但绝对数量或辅助/抑制（OKT4/OKT8）比值并无显著变化。