Silverman J, Katayama S, Radok P, Levenstein M J, Weisburger J H
Nutr Cancer. 1983;4(3):186-91.
Mammary cancer was induced in 50-day-old Sprague-Dawley rats with either 25 mg/kg body weight of N-methyl-N-nitrosourea (MNU) or 10 mg/rat of dimethylbenz(a)anthracene (DMBA). The retinoid N-(4-hydroxyphenyl)-all-trans-retinamide (RAHA) was begun in the diet (2.0 mmol/kg diet) of MNU-induced rats at 21, 48, or 52 days of age, and at 21 or 60 days of age for DMBA-induced rats. RAHA was terminated 12-17 weeks postinduction, and the animals were sacrificed at 28 weeks postinduction. Significant inhibition of tumor incidence or multiplicity was found in only one group (rats fed RAHA beginning at 48 days of age). This was not considered sufficient evidence to conclude that short-term administration of RAHA altered mammary tumor development.
采用25mg/kg体重的N-甲基-N-亚硝基脲（MNU）或10mg/只的二甲基苯并(a)蒽（DMBA）诱导50日龄的斯普拉格-道利大鼠患乳腺癌。类视黄醇N-(4-羟基苯基)-全反式视黄酰胺（RAHA）在MNU诱导的大鼠21日龄、48日龄或52日龄时开始添加到饮食中（2.0mmol/kg饮食），在DMBA诱导的大鼠21日龄或60日龄时开始添加。诱导后12 - 17周停止给予RAHA，诱导后28周处死动物。仅在一组（48日龄开始喂食RAHA的大鼠）中发现肿瘤发生率或肿瘤数量有显著抑制。这一结果不足以得出短期给予RAHA会改变乳腺肿瘤发展的结论。
