Rosenthal M, Sendelova S
Schweiz Med Wochenschr. 1983 Mar 19;113(11):394-8.
Monoclonal antibodies were used to determinee the various T-lymphocyte subpopulations in 51 patients with rheumatoid arthritis (RA). The findings were compared with an age-matched healthy control population. Patients with active rheumatoid arthritis display a significant decrease in suppressor T lymphocyte subsets as compared with RA-patients with inactive disease. The calculated immunological ratio (helper-suppressor ratio) is accordingly higher than in the inactive disease state or in normals. Remission-aimed therapy with slow-acting agents such as gold salts. D-penicillamin, levamisole or azathioprine induces not only a clinical improvement but also normalization of the immunological ratio. These findings support the hypothesis that immunological imbalance may play a crucial role in the development and perpetuation of rheumatoid arthritis.
采用单克隆抗体检测了51例类风湿性关节炎（RA）患者的各种T淋巴细胞亚群。并将结果与年龄匹配的健康对照人群进行了比较。与病情不活动的类风湿性关节炎患者相比，处于活动期的类风湿性关节炎患者的抑制性T淋巴细胞亚群显著减少。因此，计算得出的免疫比值（辅助性T细胞与抑制性T细胞比值）高于疾病不活动状态或正常状态。使用金盐、D-青霉胺、左旋咪唑或硫唑嘌呤等慢作用药物进行旨在缓解病情的治疗，不仅能使临床症状改善，还能使免疫比值恢复正常。这些发现支持了免疫失衡可能在类风湿性关节炎的发生和持续发展中起关键作用这一假说。
