Fajumi J O
Contraception. 1983 Feb;27(2):161-75. doi: 10.1016/0010-7824(83)90087-2.
A fasting plasma lipid profile investigation was undertaken in 63 women who were on contraception with the 3-monthly intramuscular depo-provera injection for periods ranging from 3 to 30 months. Fifty nulliparous women, with no previous history of contraceptive therapy, matched for age, parity, height and socio-economic status, served as controls. History of clinico-physiological side effects was recorded. The results show reduced levels of fasting plasma cholesterol in patients on depo-provera compared to the control group but there was no significant change in fasting plasma phospholipid levels. Contrary to expectations, the patients on depo-provera had higher fasting plasma triglyceride levels than controls. Excessive weight gain and irregular heavy bleeding represent major reasons for withdrawal from depo-provera therapy. The findings suggest that the alterations in the plasma lipid profile, body weight and side effects experienced by women on depo-provera may be inversely related to the duration of effective therapy.
对63名采用每3个月肌肉注射一次长效醋酸甲孕酮进行避孕、避孕时间在3至30个月的女性进行了空腹血脂水平调查。选取50名未生育、无避孕治疗史、年龄、胎次、身高和社会经济地位相匹配的女性作为对照。记录临床生理副作用史。结果显示，与对照组相比，使用长效醋酸甲孕酮的患者空腹血浆胆固醇水平降低，但空腹血浆磷脂水平无显著变化。与预期相反，使用长效醋酸甲孕酮的患者空腹血浆甘油三酯水平高于对照组。体重过度增加和不规则大量出血是停止长效醋酸甲孕酮治疗的主要原因。研究结果表明，使用长效醋酸甲孕酮的女性血浆脂质谱、体重和副作用的改变可能与有效治疗的持续时间呈负相关。
