Yadav Binod Kumar, Gupta Rajesh Kumar, Gyawali Prajwal, Shrestha Rojeet, Poudel Bibek, Sigdel Manoj, Jha Bharat
Department of Biochemistry, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
Korean J Lab Med. 2011 Apr;31(2):95-7. doi: 10.3343/kjlm.2011.31.2.95.
Various synthetic progestogens that are used as contraceptives have been reported to influence lipid and lipoprotein fractions differently. Depo-medroxyprogesterone acetate (DMPA), a synthetic progestogen, is used by Nepalese women as a contraceptive agent. Our study aims to determine the effects of long-term use of DMPA on lipid metabolism. We performed this study on 60 healthy Nepalese women who had been using DMPA for more than 2 yr and age- and weight-matched control subjects who were not using hormonal contraceptives. Fasting blood samples were collected from the subjects for the estimation of total cholesterol (TC) and triglyceride (TG) levels, and the levels of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were estimated using the Friedewald's equation. TC and LDL-C levels in DMPA users were significantly higher than those in non-users. Our study concluded that DMPA use induces lipid metabolism changes that can increase the risk of cardiovascular diseases.
据报道，各种用作避孕药的合成孕激素对脂质和脂蛋白组分的影响各不相同。醋酸甲羟孕酮长效注射液（DMPA），一种合成孕激素，被尼泊尔女性用作避孕剂。我们的研究旨在确定长期使用DMPA对脂质代谢的影响。我们对60名健康的尼泊尔女性进行了这项研究，这些女性使用DMPA超过2年，以及年龄和体重匹配的未使用激素避孕药的对照受试者。从受试者采集空腹血样以估计总胆固醇（TC）和甘油三酯（TG）水平，并使用弗里德瓦尔德方程估计高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平。DMPA使用者的TC和LDL-C水平显著高于未使用者。我们的研究得出结论，使用DMPA会引起脂质代谢变化，从而增加心血管疾病的风险。
