Merino F, Lipscomb H, Amesty C, Purtilo D, Ramírez-Duque P
Immunol Lett. 1983 Feb;6(2):81-5. doi: 10.1016/0165-2478(83)90085-8.
Peripheral blood lymphocyte subsets were studied in 6 Chediak-Higashi patients and 12 family members. The lymphocyte subsets were characterized by monoclonal antibody reagents and fluorescence flow-cytometry. An increase in OKT8 (suppressor/cytotoxic) and a decrease in OKT4 (helper) cell populations was observed in all patients studied. No correlation was seen between the clinical status (presence or absence of the lymphoproliferative phase) and the percentage of the lymphocyte subsets. The patient's mothers also had an increased percentage of OKT8-positive cells. The significance of these findings is discussed regarding the patients clinical course.
对6例切-希二氏综合征患者和12名家庭成员的外周血淋巴细胞亚群进行了研究。采用单克隆抗体试剂和荧光流式细胞术对淋巴细胞亚群进行表征。在所有研究患者中均观察到OKT8（抑制/细胞毒性）细胞增加，OKT4（辅助）细胞群体减少。临床状态（是否存在淋巴增殖期）与淋巴细胞亚群百分比之间未发现相关性。患者的母亲OKT8阳性细胞百分比也增加。就患者的临床病程对这些发现的意义进行了讨论。
