Gattringer C, Huber H
Wien Klin Wochenschr. 1983 Mar 4;95(5):138-44.
Suppressor cells can be identified in vitro either by specific antibodies or by functional test assays. On investigation of the latter, a close relationship was demonstrated between spontaneously active and in vitro induced (ConA) suppressor cells. The activity of these cells, however, showed a wide day to day variation. Hence, no clinically relevant conclusions could be drawn from a comparison of patients and controls. This was shown both for SLE and myeloma. However, in multiple myeloma indirect evidence of increased activity of short-lived suppressor cells emerged from a different methodological approach. Helper and suppressor cells were evaluated using monoclonal antibodies. Patients with Hodgkin's disease in long-term remission had decreased proportions of T-lymphocytes. Helper T-cells but not suppressor T-cells were strongly diminished. The helper-suppressor ratio was changed from 2.1 in controls to 1.2 in patients. The stimulation (PHA-stimulation) index of the patients was half of the control value. The interactions of suppressor and tumour cells were investigated in non-Hodgkin's lymphoma. In general, a marked reactive infiltration of neoplastic lymph nodes was found. The pattern of suppressor cell distribution argued in favour of a functional role of these cells in tumour growth.
抑制细胞可以在体外通过特异性抗体或功能测试分析来识别。在对后者进行研究时，发现自发活跃的抑制细胞与体外诱导（刀豆球蛋白A）的抑制细胞之间存在密切关系。然而，这些细胞的活性表现出很大的每日波动。因此，从患者与对照的比较中无法得出临床相关的结论。这在系统性红斑狼疮和骨髓瘤中均有体现。然而，在多发性骨髓瘤中，通过不同的方法学途径出现了短命抑制细胞活性增加的间接证据。使用单克隆抗体评估辅助细胞和抑制细胞。长期缓解的霍奇金病患者的T淋巴细胞比例降低。辅助性T细胞而非抑制性T细胞显著减少。辅助细胞与抑制细胞的比例从对照组的2.1变为患者组的1.2。患者的刺激（植物血凝素刺激）指数是对照值的一半。在非霍奇金淋巴瘤中研究了抑制细胞与肿瘤细胞的相互作用。总体而言，发现肿瘤淋巴结有明显的反应性浸润。抑制细胞的分布模式表明这些细胞在肿瘤生长中具有功能性作用。
