Surányi P, Mátyus L, Sonkoly I, Szegedi G
Clin Exp Immunol. 1984 Oct;58(1):37-41.
The ratio of in vivo activated T helper, T suppressor and B cells in the blood of patients with SLE has been studied through simultaneous subset specific immunofluorescence labelling and the analysis of cellular DNA content with the help of flow fluorimetry. In the active stage of the disease an increase was observed in the proportion of proliferating cells either among the T helper cells or the B cells. Occasionally, however, the rate of proliferation in both subsets grew at the same time. Cases with a high number of activated B cells have proved to be more serious. The percentage of the T suppressor cells in the S-G2-M phase of the cell cycle increased moderately in both the active and the inactive stages of the disease. Our results are also discussed in relation to the pathogenetic mechanism of SLE.
通过同时进行亚群特异性免疫荧光标记并借助流式荧光测定法分析细胞DNA含量，对系统性红斑狼疮（SLE）患者血液中体内活化的辅助性T细胞、抑制性T细胞和B细胞的比例进行了研究。在疾病的活动期，观察到辅助性T细胞或B细胞中增殖细胞的比例增加。然而，偶尔两个亚群的增殖率会同时升高。已证明活化B细胞数量较多的病例病情更严重。在疾病的活动期和非活动期，细胞周期S-G2-M期的抑制性T细胞百分比均适度增加。我们还结合SLE的发病机制对研究结果进行了讨论。
