Reibel D K, Uboh C E, Kent R L
Am J Physiol. 1983 Jun;244(6):H839-43. doi: 10.1152/ajpheart.1983.244.6.H839.
Changes in the total content and acylation state of coenzyme A (CoA) and carnitine in the heart result in alterations in fatty acid metabolism that may be associated with ventricular dysfunction. The present study was undertaken to determine whether abnormal myocardial CoA and carnitine metabolism occur in pressure-overload hypertrophy and congestive heart failure. Right ventricular hypertrophy was induced in cats by pulmonary artery (PA) banding. Total tissue CoA was reduced by 50% in the hypertrophied right ventricle and 25% in the nonhypertrophied left ventricle of PA-banded cats in the presence or absence of heart failure. No alterations were observed in long-chain fatty acyl CoA levels in either ventricle of PA-banded cats. In addition, a 20% reduction in total CoA was also observed in hypertrophied hearts of rats subjected to aortic banding. Although the CoA content was reduced in hypertrophied cat hearts, myocardial tissue levels of its precursor, pantothenic acid, were unaltered. Total tissue carnitine and long-chain fatty acyl-carnitine levels were unchanged in both ventricles of PA-banded cats; however, total carnitine was reduced by 25% in hypertrophied rat hearts. This study establishes a marked reduction in myocardial CoA content in pressure-overload hypertrophy.
心脏中辅酶A（CoA）和肉碱的总含量及酰化状态的变化会导致脂肪酸代谢改变，这可能与心室功能障碍有关。本研究旨在确定在压力超负荷肥大和充血性心力衰竭中是否会发生心肌CoA和肉碱代谢异常。通过肺动脉（PA）结扎诱导猫右心室肥大。在存在或不存在心力衰竭的情况下，PA结扎猫的肥大右心室中总组织CoA降低了50%，未肥大的左心室中降低了25%。PA结扎猫的任一心室中长链脂肪酰CoA水平均未观察到改变。此外，在接受主动脉结扎的大鼠肥大心脏中也观察到总CoA降低了20%。尽管肥大的猫心脏中CoA含量降低，但其前体泛酸的心肌组织水平未改变。PA结扎猫的两个心室中总组织肉碱和长链脂肪酰肉碱水平均未改变；然而，肥大的大鼠心脏中总肉碱降低了25%。本研究证实压力超负荷肥大时心肌CoA含量显著降低。
