Sato S, Koga T, Inoue M
Arch Oral Biol. 1983;28(3):211-6. doi: 10.1016/0003-9969(83)90149-8.
Twenty-eight strains of facultative, Gram-positive, sporulating bacilli which produce caseinolytic enzymes were isolated from human early dental plaque. A major component of the extracellular caseinolytic enzymes elaborated by strong producers seemed to be neutral zinc proteases. The extracellular proteases inactivated glucosyltransferase of Streptococcus mutans and inhibited the synthesis of adherent glucans from sucrose. The enzymes also degraded the Strep. mutans cell-surface receptor for dextran and glucan, the receptor for salivary agglutinins, located on Streptococcus sanguis cells, and the surface component of Actinomyces viscosus cells involved in co-agglutination with Strep. sanguis cells. The enzymes hydrolysed human whole saliva proteins, which seemed to result in loss of the ability to agglutinate Strep. sanguis cells.
从人类早期牙菌斑中分离出28株兼性、革兰氏阳性、产芽孢杆菌，这些菌株可产生酪蛋白分解酶。高产菌株所分泌的细胞外酪蛋白分解酶的主要成分似乎是中性锌蛋白酶。细胞外蛋白酶可使变形链球菌的葡糖基转移酶失活，并抑制由蔗糖合成黏附性葡聚糖。这些酶还可降解变形链球菌的葡聚糖和葡聚糖细胞表面受体、血链球菌细胞上唾液凝集素的受体以及黏性放线菌细胞表面参与与血链球菌细胞共凝集的成分。这些酶可水解人类全唾液蛋白，这似乎导致了凝集血链球菌细胞能力的丧失。
