唾液凝集素介导变形链球菌与早期菌斑细菌的黏附。
Salivary-agglutinin-mediated adherence of Streptococcus mutans to early plaque bacteria.
作者信息
Lamont R J, Demuth D R, Davis C A, Malamud D, Rosan B
机构信息
Department of Oral Biology, School of Dentistry, University of Washington, Seattle 98195.
出版信息
Infect Immun. 1991 Oct;59(10):3446-50. doi: 10.1128/iai.59.10.3446-3450.1991.
Interspecies binding is important in the colonization of the oral cavity by bacteria. Streptococcus mutans can adhere to other plaque bacteria, such as Streptococcus sanguis and Actinomyces viscosus, and this adherence is enhanced by saliva. The salivary and bacterial molecules that mediate this interaction were investigated. Salivary agglutinin, a mucinlike glycoprotein known to mediate the aggregation of many oral streptococci in vitro, was found to mediate the adherence of S. mutans to S. sanguis or A. viscosus. Adherence of S. mutans to saliva- or agglutinin-coated S. sanguis and A. viscosus was inhibited by antibodies to the bacterial agglutinin receptor. Expression of the S. sanguis receptor (SSP-5) gene in Enterococcus faecalis increased adhesion of this organism to saliva- or agglutinin-coated S. sanguis and A. viscosus. This interaction could be inhibited by antibodies to the agglutinin receptor. The results suggest that salivary agglutinin can promote adherence of S. mutans to S. sanguis and A. viscosus through interactions with the agglutinin receptor on S. mutans.
种间结合在细菌在口腔中的定植过程中很重要。变形链球菌可以黏附于其他菌斑细菌，如血链球菌和黏性放线菌，并且这种黏附会因唾液而增强。对介导这种相互作用的唾液和细菌分子进行了研究。唾液凝集素是一种黏蛋白样糖蛋白，已知在体外介导许多口腔链球菌的聚集，发现它能介导变形链球菌与血链球菌或黏性放线菌的黏附。针对细菌凝集素受体的抗体可抑制变形链球菌对唾液包被或凝集素包被的血链球菌和黏性放线菌的黏附。粪肠球菌中血链球菌受体（SSP-5）基因的表达增加了该菌对唾液包被或凝集素包被的血链球菌和黏性放线菌的黏附。这种相互作用可被针对凝集素受体的抗体抑制。结果表明，唾液凝集素可通过与变形链球菌上的凝集素受体相互作用，促进变形链球菌对血链球菌和黏性放线菌的黏附。
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