Lehmann W, Graetz H, Schunck H, Schütt M, Langen P
Acta Histochem Suppl. 1983;27:63-71.
The following aspects of action of a chalone-like factor for the Ehrlich ascites mammary carcinoma and of the granulocytic chalone are discussed: 1) Dependence on the state of proliferation. Rapidly growing cells respond poorly or not at all. 2) Antagonism with growth factors. The factor for the Ehrlich ascites mammary carcinoma is antagonized by physiological concentrations of insulin or by proinsulin. The granulocytic chalone is antagonized by colony stimulating factor. 3) Influence on cell cycle progression. Attempts and problems to analyse this influence for the factor for the Ehrlich ascites mammary carcinoma by flow cytometry are described.
1）对增殖状态的依赖性。快速生长的细胞反应不佳或根本无反应。2）与生长因子的拮抗作用。艾氏腹水乳腺癌的因子可被生理浓度的胰岛素或胰岛素原拮抗。粒细胞抑素可被集落刺激因子拮抗。3）对细胞周期进程的影响。描述了通过流式细胞术分析艾氏腹水乳腺癌因子对这一影响的尝试及问题。
