Nagao T, Komatsuda M, Yamauchi K, Nozaki H
Chemotherapy. 1983;29(3):230-5. doi: 10.1159/000238202.
27 episodes of infection in patients with acute leukemia were treated with combination of cefmetazole and piperacillin. Causative bacteria were isolated in each infection. The patients were treated with 6 g cefmetazole and 15 g piperacillin per day in three divided doses. Among the episodes of infection, 21 (78%) of 27 responded to cefmetazole and piperacillin. Adverse reactions were skin rash in 2 patients, transient elevation of serum glutamic-pyruvic transaminase in 3 patients and elevation of creatinine in 1 patient. Cefmetazole and piperacillin appear to be an effective combination, with acceptable adverse reactions, for the empiric therapy of infection in patients with acute leukemia.
采用头孢美唑与哌拉西林联合治疗急性白血病患者的27例感染病例。每次感染均分离出病原菌。患者每天接受6g头孢美唑和15g哌拉西林治疗，分3次给药。在感染病例中，27例中有21例（78%）对头孢美唑和哌拉西林有反应。不良反应包括2例患者出现皮疹，3例患者血清谷丙转氨酶短暂升高，1例患者肌酐升高。头孢美唑和哌拉西林似乎是治疗急性白血病患者感染经验性治疗的有效联合用药，不良反应可接受。
