Nagao T, Komatsuda M, Yamauchi K, Nozaki H, Arimori S
Tokai J Exp Clin Med. 1981 Oct;6(4):415-20.
The combination of cefmetazole and piperacillin was compared with the combination of cefmetazole, piperacillin and tobramycin in the treatment of 20 patients with hematological disorders. The response rate was similar for both treatments (90% vs. 80%), and the difference was not statistically significant. The rate of serum glutamic pyruvic transaminase elevation was higher in patients treated with cefmetazole, piperacillin and tobramycin than in those treated with cefmetazole and piperacillin. Cefmetazole and piperacillin without tobramycin appear to be an effective combination with acceptable toxicity for empirical therapy of febrile episodes occurring in patients with hematological disorders.
将头孢美唑和哌拉西林的联合用药与头孢美唑、哌拉西林和妥布霉素的联合用药在20例血液系统疾病患者的治疗中进行了比较。两种治疗的有效率相似（分别为90%和80%），差异无统计学意义。接受头孢美唑、哌拉西林和妥布霉素治疗的患者血清谷丙转氨酶升高率高于接受头孢美唑和哌拉西林治疗的患者。对于血液系统疾病患者发生的发热性发作的经验性治疗，不含妥布霉素的头孢美唑和哌拉西林似乎是一种具有可接受毒性的有效联合用药。
