变形链球菌潜在致龋特性的基因转化
Genetic transformation of putative cariogenic properties in Streptococcus mutans.
作者信息
Perry D, Wondrack L M, Kuramitsu H K
出版信息
Infect Immun. 1983 Aug;41(2):722-7. doi: 10.1128/iai.41.2.722-727.1983.
Abstract
Rough colonial morphology and bacteriocin production, two properties which may be associated with the cariogenicity of Streptococcus mutans, were transformed into several strain GS-5 mutants defective in each respective property. Transformation was determined by observing the frequency of cotransfer of these properties with different reference markers. The rough colonial transformants were identical to the parental GS-5 strain with respect to ability to synthesize water-insoluble glucans and undergo in vitro sucrose-dependent colonization of glass surfaces. Alterations in the growth medium and the concentration of the initial cell inoculum resulted in an approximate 10-fold increase in the frequency of transformation of strain GS-5 compared to previous observations.
摘要
粗糙的菌落形态和细菌素产生这两个可能与变形链球菌致龋性相关的特性，被转化到了几种在各自特性上有缺陷的GS-5菌株突变体中。通过观察这些特性与不同参考标记的共转移频率来确定转化情况。粗糙菌落转化体在合成水不溶性葡聚糖和在体外玻璃表面进行蔗糖依赖性定植的能力方面与亲本GS-5菌株相同。与之前的观察结果相比，生长培养基和初始细胞接种物浓度的改变导致GS-5菌株的转化频率大约增加了10倍。
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