Navarro J, Touraine J L
Int J Immunopharmacol. 1983;5(2):157-62. doi: 10.1016/0192-0561(83)90008-5.
The effect of Cyclomunine (Cym) and Cyclosporin A (CyA) on in vitro human lymphocyte proliferation was assessed and it was noted that Cym and CyA suppressed lymphocyte response to mitogens, allogeneic cells or antigen in a dose--and time--dependent fashion. Furthermore, using a secondary mixed lymphocyte reaction model, we showed that neither CyA nor Cym exerted their immunosuppressive activity by producing specific clonal deletion and that their constant presence was necessary to obtain an antilymphocytic activity. These data suggest that treatment with these drugs in allotransplantation should be on a continuous basis.
评估了环孢灵（Cym）和环孢素A（CyA）对体外人淋巴细胞增殖的影响，发现Cym和CyA以剂量和时间依赖性方式抑制淋巴细胞对有丝分裂原、同种异体细胞或抗原的反应。此外，使用二次混合淋巴细胞反应模型，我们表明CyA和Cym均未通过产生特异性克隆缺失发挥其免疫抑制活性，且它们的持续存在对于获得抗淋巴细胞活性是必要的。这些数据表明，在同种异体移植中使用这些药物进行治疗应持续进行。
