Kleefield J, Chirico-Post J, Levine H L, Srinivasan M K, Harris J M, Rommel A J, Robbins A H
Surg Neurol. 1983 Aug;20(2):165-70. doi: 10.1016/0090-3019(83)90471-8.
Iopamidol is a new, nonionic, water-soluble contrast material currently undergoing clinical trials for intravascular and intrathecal use in Europe and the United States. In this study, 12 patients underwent lumbar myelography with this agent. For each subject, up to 12 mL of iopamidol (at 200 mg I/mL) was employed. The myelograms obtained were highly satisfactory. No serious adverse reactions were observed. The most common side effect--headache--occurred in seven patients. However, six of the seven headaches were mild and transient, and did not require treatment. Nausea occurred in two patients, back pain in two patients, hypotension and hypertension each in one patient. All of these reactions were mild and self-limited. Iopamidol appears to be a safe and conveniently used agent for lumbar myelography.
碘帕醇是一种新型的非离子型水溶性造影剂，目前正在欧洲和美国进行血管内和鞘内使用的临床试验。在本研究中，12例患者使用该药物进行了腰椎脊髓造影。对于每个受试者，使用了多达12毫升的碘帕醇（200毫克碘/毫升）。所获得的脊髓造影片非常令人满意。未观察到严重不良反应。最常见的副作用——头痛——发生在7例患者中。然而，7例头痛患者中有6例为轻度且短暂，无需治疗。2例患者出现恶心，2例患者出现背痛，1例患者出现低血压，1例患者出现高血压。所有这些反应均为轻度且可自行缓解。碘帕醇似乎是一种用于腰椎脊髓造影的安全且使用方便的药物。
