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在Goodpasture综合征初始阶段抗肾小球基底膜和免疫复合物介导发病机制的证据。

Evidence of both anti-GBM and immune complex mediated pathogenesis in the initial phase of Goodpasture's syndrome.

作者信息

Pasternack A, Törnroth T, Linder E

出版信息

Clin Nephrol. 1978 Feb;9(2):77-85.

PMID:147761
Abstract

A 19 year old women presented with pulmonary hemorrhage, rapidly progressive glomerulonephritis and antiglomerular basement membrane antibody in her serum. In the initial phase of the disease a double layered linear deposit of IgG was seen on the glomerular capillary basement membrane together with a finely granular or focal and lumpy single layer deposit of C3 and numerous small subepithelial electron dense deposits. These findings are suggestive of the simultaneous occurrence of anti-GBM and immune complex glomerulonephritis.

摘要

一名19岁女性出现肺出血、快速进展性肾小球肾炎,血清中存在抗肾小球基底膜抗体。在疾病初期,在肾小球毛细血管基底膜上可见IgG的双层线性沉积,同时伴有C3的细颗粒状或局灶性块状单层沉积以及大量小的上皮下电子致密沉积物。这些发现提示抗肾小球基底膜和免疫复合物性肾小球肾炎同时存在。

相似文献

1
Evidence of both anti-GBM and immune complex mediated pathogenesis in the initial phase of Goodpasture's syndrome.在Goodpasture综合征初始阶段抗肾小球基底膜和免疫复合物介导发病机制的证据。
Clin Nephrol. 1978 Feb;9(2):77-85.
2
Goodpasture's syndrome--local and diffuse deposition of antibody in glomerular basement membrane. Case report.肺出血肾炎综合征——抗体在肾小球基底膜的局部及弥漫性沉积。病例报告。
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The evolution of crescentic nephritis and alveolar haemorrhage following induction of autoimmunity to glomerular basement membrane in an experimental model of Goodpasture's disease.在古德帕斯彻氏病实验模型中,诱导针对肾小球基底膜的自身免疫后新月体性肾炎和肺泡出血的演变。
J Pathol. 2003 May;200(1):118-29. doi: 10.1002/path.1336.
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Concurrent antiglomerular basement membrane antibody and immune complex mediated glomerulonephritis.合并抗肾小球基底膜抗体和免疫复合物介导的肾小球肾炎。
Am J Clin Pathol. 1982 Sep;78(3):381-6. doi: 10.1093/ajcp/78.3.381.
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The appearance of nonlinear deposits of immunoglobulins in Goodpasture's syndrome.古德帕斯彻综合征中免疫球蛋白非线性沉积物的出现。
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Goodpasture's syndrome with asymptomatic renal involvement. Disappearance of antiglomerular basement membrane antibodies deposits after treatment.伴有无症状性肾脏受累的Goodpasture综合征。治疗后抗肾小球基底膜抗体沉积物消失。
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Goodpasture's disease in the absence of circulating anti-glomerular basement membrane antibodies as detected by standard techniques.经标准技术检测,无循环抗肾小球基底膜抗体情况下的肺出血肾炎综合征。
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Goodpasture's syndrome with concomitant immune complex mixed membranous and proliferative glomerulonephritis.伴有免疫复合物混合性膜性和增殖性肾小球肾炎的肺出血肾炎综合征。
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[Goodpasture's syndrome. Antiglomerular basal membrane antibody-mediated glomerulonephritis].[古德帕斯丘综合征。抗肾小球基底膜抗体介导的肾小球肾炎]
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Linear anti-glomerular basement membrane IgG but no glomerular disease: Goodpasture's syndrome restricted to the lung.线性抗肾小球基底膜IgG但无肾小球疾病:局限于肺部的肺出血肾炎综合征
Nephrol Dial Transplant. 2007 Apr;22(4):1233-5. doi: 10.1093/ndt/gfl841. Epub 2007 Feb 3.

引用本文的文献

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Diagnosis of membranous nephropathy with Anti-GBM glomerulonephritis: a case series report.诊断抗肾小球基底膜肾小球肾炎相关性膜性肾病:病例系列报告。
BMC Nephrol. 2024 Jun 21;25(1):204. doi: 10.1186/s12882-024-03637-4.
2
The Characteristics of Concurrent Anti-Glomerular Basement Membrane Nephritis and Membranous Nephropathy.抗肾小球基底膜肾炎与膜性肾病并存的特征
Kidney Int Rep. 2023 Aug 11;8(10):2164-2167. doi: 10.1016/j.ekir.2023.07.031. eCollection 2023 Oct.
3
A case of anti-GBM glomerulonephritis superimposed on HBV-associated membranous nephropathy.
1例抗肾小球基底膜(GBM)肾小球肾炎叠加于乙肝病毒相关性膜性肾病。
CEN Case Rep. 2013 Nov;2(2):239-247. doi: 10.1007/s13730-013-0071-4. Epub 2013 Apr 13.
4
A case of antiglomerular basement membrane glomerulonephritis complicated by membranous nephropathy.1例抗肾小球基底膜肾小球肾炎合并膜性肾病。
CEN Case Rep. 2014 May;3(1):94-99. doi: 10.1007/s13730-013-0094-x. Epub 2013 Oct 5.
5
Anti-glomerular basement membrane disease superimposed on membranous nephropathy: a case report and review of the literature.抗肾小球基底膜病叠加膜性肾病:一例报告并文献复习
J Med Case Rep. 2010 Aug 2;4:237. doi: 10.1186/1752-1947-4-237.
6
Circulating immune complexes appearing in Goodpasture's syndrome.循环免疫复合物出现在肺出血肾炎综合征中。
Br Med J. 1980 May 10;280(6224):1166-7. doi: 10.1136/bmj.280.6224.1166.
7
Glomerulonephritis with coexistent immune deposits and antibasement membrane activity.伴有免疫沉积物和抗基底膜活性共存的肾小球肾炎。
J Clin Pathol. 1984 Feb;37(2):176-81. doi: 10.1136/jcp.37.2.176.
8
The interaction of anti-glomerular basement membrane antibody deposition with immune elimination of bovine serum albumin in the rabbit.抗肾小球基底膜抗体沉积与兔体内牛血清白蛋白免疫清除的相互作用。
Clin Exp Immunol. 1979 Mar;35(3):338-49.