Lunn P G, Austin S
J Nutr. 1983 Sep;113(9):1791-802. doi: 10.1093/jn/113.9.1791.
The variation in plasma albumin concentrations of rats fed a wide range of protein- and energy-deficient diets has been investigated. These changes have been correlated with simultaneous effects of the diets on growth rate, carcass composition, protein and energy balance, and plasma concentration of insulin corticosterone and triiodothyronine (T3). Although rats eating diets of low protein content and libitum developed hypoalbuminemia, those fed equivalent amounts of protein at low energy intakes had plasma albumin concentrations nearer, or equal to control values. Data from the balance study showed that for hypoalbuminemia to occur, not only had dietary protein to be inadequate, it was also necessary for energy consumption to be in excess of requirements. It is suggested that in protein-deficient animals, energy consumed in excess of the amount required for maintenance and the protein-limited growth rate initiates a metabolic response which results in inappropriate use of the meagre protein intake. This "dysadapted" state, in the rat, appears to be indicated by elevated plasma T3 values. The implication that kwashiorkor-like symptoms can be generated by a relative as opposed to a total energy excess is discussed in relation to the appearance of this disease in humans.
对喂食多种蛋白质和能量缺乏饮食的大鼠血浆白蛋白浓度的变化进行了研究。这些变化与饮食对生长速率、胴体组成、蛋白质和能量平衡以及胰岛素、皮质酮和三碘甲状腺原氨酸（T3）血浆浓度的同时影响相关。尽管自由采食低蛋白含量饮食的大鼠出现了低白蛋白血症，但那些以低能量摄入量喂食等量蛋白质的大鼠血浆白蛋白浓度更接近或等于对照值。平衡研究的数据表明，要发生低白蛋白血症，不仅饮食蛋白质必须不足，能量消耗也必须超过需求。有人提出，在蛋白质缺乏的动物中，超过维持和蛋白质限制生长速率所需量的能量消耗引发了一种代谢反应，导致对少量蛋白质摄入量的不适当利用。在大鼠中，这种“适应不良”状态似乎由血浆T3值升高表明。结合人类这种疾病的出现，讨论了相对而非总能量过剩可产生类似夸希奥科病症状的含义。
