Edozien J C, Niehaus N, Mar M H, Makoui T, Switzer B R
J Nutr. 1978 Nov;108(11):1767-76. doi: 10.1093/jn/108.11.1767.
Twenty-eight-day old male rats were fed, either ad libitum or in restricted amounts, isoenergetic diets containing 2, 5, 10, 15, 25, or 50% lactalbumin and 5, 11.9, or 21.1% fat for 8 weeks. They were then killed and the plasma levels of triiodothyronine (T3), thyroxine (T4), insulin, glucagon, corticosterone, norepinephrine (NE), and epinephrine (E) were measured. Dietary changes explained most of the variation in the plasma concentrations of T3, T4, insulin, and glucagon but less than 20% of the variation in the plasma concentrations of the adrenal hormones. Dietary protein level was directly related to plasma T4, insulin and corticosterone and inversely related to plasma T3, glucagon, NE, and E. Dietary fat level had its most significant effect on the plasma glucagon concentration to which it was inversely related whereas the most noteworthy effect of a low energy intake was to reduce plasma E and thereby to increase the NE/E ratio. A refeeding study confirmed the effects of dietary protein level on plasma hormone concentrations and showed that the changes in diet-hormone interrelationships in 12-week old male rats have been derived by multiple regression analyses of the data.
给28日龄的雄性大鼠随意或限量喂食等能量日粮，日粮含2%、5%、10%、15%、25%或50%的乳白蛋白以及5%、11.9%或21.1%的脂肪，持续8周。然后将它们处死，测量血浆中三碘甲状腺原氨酸（T3）、甲状腺素（T4）、胰岛素、胰高血糖素、皮质酮、去甲肾上腺素（NE）和肾上腺素（E）的水平。饮食变化解释了血浆中T3、T4、胰岛素和胰高血糖素浓度变化的大部分原因，但对血浆中肾上腺激素浓度变化的解释不到20%。饮食蛋白质水平与血浆T4、胰岛素和皮质酮直接相关，与血浆T3、胰高血糖素、NE和E呈负相关。饮食脂肪水平对血浆胰高血糖素浓度影响最为显著，二者呈负相关，而低能量摄入最值得注意的影响是降低血浆E水平，从而提高NE/E比值。一项再喂养研究证实了饮食蛋白质水平对血浆激素浓度的影响，并表明12周龄雄性大鼠饮食与激素相互关系的变化是通过对数据进行多元回归分析得出的。
