Hillemeier C, Buchin P J, Gryboski J
J Pediatr Gastroenterol Nutr. 1982;1(1):101-4. doi: 10.1097/00005176-198201010-00017.
Abnormalities in esophageal function were identified in seven children with Down's syndrome. Three had recurrent episodes of pneumonia from gastroesophageal reflux; two of these and one other patient had esophageal strictures. Two patients with Down's syndrome revealed no evidence of gastroesophageal reflux but did show significant abnormalities in esophageal peristalsis. These data would suggest that ambulatory children with Down's syndrome may be at risk of developing serious sequellae of gastroesophageal reflux. The spectrum of data of these seven patients is discussed, and pertinent prior reports from the literature are reviewed.
在7名唐氏综合征患儿中发现了食管功能异常。3名患儿因胃食管反流反复发生肺炎；其中2名以及另1名患者存在食管狭窄。2名唐氏综合征患者未发现胃食管反流证据，但食管蠕动存在明显异常。这些数据表明，患有唐氏综合征的能走动儿童可能有发生胃食管反流严重后遗症的风险。本文讨论了这7名患者的数据范围，并回顾了文献中相关的既往报道。
