Thomas C T, Berk S L, Thomas E
Arch Intern Med. 1983 Sep;143(9):1780-1.
Moxalactam, a third-generation cephalosporin, has been demonstrated to have an ultrawide spectrum of antibacterial activity. One important gap in this impressive spectrum is the enterococcus. Superinfections and colonization with enterococci have been reported following moxalactam therapy. Sites involved have included the urinary tract, wounds, middle ear, and blood stream. To our knowledge, we report the first case of enterococcal liver abscess following moxalactam therapy. The abscess was localized by ultrasound examination and microbiologic diagnosis made by aspiration using a skinny needle. Without surgical drainage or therapeutic aspiration, institution of appropriate antibiotic therapy in optimum dosage resulted in complete resolution. The literature on enterococcal superinfections in association with moxalactam therapy and nonsurgical management of liver abscesses is reviewed.
莫西拉坦是一种第三代头孢菌素，已被证明具有超广谱抗菌活性。在这一令人印象深刻的抗菌谱中，一个重要的空白是肠球菌。据报道，莫西拉坦治疗后出现了肠球菌的二重感染和定植。受累部位包括泌尿道、伤口、中耳和血流。据我们所知，我们报告了首例莫西拉坦治疗后发生的肠球菌肝脓肿病例。通过超声检查定位脓肿，并使用细针穿刺进行微生物学诊断。在未进行手术引流或治疗性穿刺的情况下，采用最佳剂量的适当抗生素治疗使脓肿完全消退。本文对与莫西拉坦治疗相关的肠球菌二重感染及肝脓肿非手术治疗的文献进行了综述。
