Wick M M
Science. 1978 Feb 17;199(4330):775-6. doi: 10.1126/science.622565.
L-Dopa has has been shown to demonstrate enhanced toxicity toward melanoma cells in vitro. Since melanocytes arise from the neural crest embryologically, the effect of L-dopa methyl ester, a soluble analog, on the murine C1300 neuroblastoma was studied. There was significant antitumor activity against the neuroblastoma, which was enhanced by combination with a dopa decarboxylase inhibitor, Ro4-4602. In vitro studies suggested inhibition of DNA synthesis as the principal site of action. A mechanism involving sulfhydryl compound scavenging is postulated.
左旋多巴已被证明在体外对黑色素瘤细胞具有增强的毒性。由于黑色素细胞在胚胎学上起源于神经嵴，因此研究了一种可溶性类似物左旋多巴甲酯对小鼠C1300神经母细胞瘤的作用。对神经母细胞瘤有显著的抗肿瘤活性，与多巴脱羧酶抑制剂Ro4-4602联合使用可增强这种活性。体外研究表明，抑制DNA合成是主要作用位点。推测其作用机制涉及清除巯基化合物。
