Meerson F Z, Pshennikova M G, Rysmendiev A Zh, Vorontsova E Ia
Kardiologiia. 1983 Jul;23(7):86-90.
The effect of preliminary administration of the adrenoblocker inderal, the lipase inhibitor nicotinamide, and the phospholipase inhibitor chloroquine on the disturbance of the myocardium extensibility and contractile function, the decrease of its resistance to hypoxia and to the calcium excess usually caused by emotional-painful stress was studied on the isolated rat atrium. It was established that these drugs prevented the above post-stress disturbances without significant affection of control animals. Nicotinamide was found to be the most effective, its protective action on the myocardium was accompanied by the prevention of the stress-induced increase of free fatty acids in the blood. The whole complex of data suggests that together with the activation of lipid peroxidation, the activation of lipases and phospholipases the damaging action of fatty acids play a role in the stress-induced damage; it also gives bases to use the factors stabilizing the membranous lipid bilayer for the heart protection against the stress-induced damages.
在离体大鼠心房上研究了预先给予肾上腺素能阻滞剂心得安、脂肪酶抑制剂烟酰胺和磷脂酶抑制剂氯喹对心肌伸展性和收缩功能紊乱、对通常由情绪痛苦应激引起的缺氧和钙过量耐受性降低的影响。结果表明，这些药物可预防上述应激后紊乱，而对对照动物无明显影响。发现烟酰胺最有效，其对心肌的保护作用伴随着预防应激诱导的血液中游离脂肪酸增加。所有数据表明，除了脂质过氧化激活外，脂肪酶和磷脂酶的激活以及脂肪酸的损伤作用在应激诱导的损伤中起作用；这也为使用稳定膜脂双层的因素来保护心脏免受应激诱导的损伤提供了依据。
