Frexinos J
Presse Med. 1983 Sep 10;12(31):1927-31.
For more than thirty years the pathophysiology of the so-called "irritable bowel syndrome" has given rise to numerous theories. These can be summarized in a series of questions to which this review paper does not pretend to provide definite answers. Is there a basic myoelectric anomaly specific to the irritable bowel syndrome? Are there disorders of colon motility that characterize the symptoms experienced by the patient? Are specific tests available that would stimulate colonic contractions in a reproducible and comparative manner? What place should be given to disturbances in bowel sensitivity? Is the colon the only target-organ in functional intestinal disorders? Is the role of digestive hormones underrated or at least insufficiently known? Do patients with the syndrome have a special psychological profile? Has intolerance to various foodstuffs been excluded too hastily? The secrets of the irritable colon syndrome are far from being entirely unravelled. This heterogeneous group of symptoms seems to be due to many different causes associated to varying degrees in each patient.
三十多年来，所谓“肠易激综合征”的病理生理学引发了众多理论。这些理论可以归纳为一系列问题，而本综述文章并不打算为这些问题提供确切答案。是否存在肠易激综合征特有的基本肌电异常？是否存在以患者所经历症状为特征的结肠动力障碍？是否有能以可重复且具有可比性的方式刺激结肠收缩的特定检测方法？肠道敏感性紊乱应占何种地位？结肠是否是功能性肠道疾病的唯一靶器官？消化激素的作用是否被低估或至少未得到充分了解？该综合征患者是否具有特殊的心理特征？对各种食物不耐受的情况是否被过于草率地排除了？结肠易激综合征的奥秘远未完全揭开。这一症状各异的群体似乎是由许多不同原因导致的，且在每位患者身上这些原因的关联程度各不相同。
